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Vol. 11 No. 1 (2023): Jurnal Keperawatan Padjadjaran

The relationship between sequential organ failure assessment (SOFA) score and mortality in covid-19 patients with ARDS

October 20, 2022


Background: The WHO declared a COVID-19 pandemic on January 30, 2020. Five percent of all patients with coronavirus disease-19 symptoms are emergency and critical cases of ARDS by 49% mortality. The SOFA score is an assessment in intensive care unit patients to determine the level of organ failure.Purpose:The research aimed to determine the relationship between SOFA scores and mortality in coronavirus disease-19 patients with ARDS.Methods: This type of research was quantitative with a retrospective cohort design. The population was coronavirus disease-19 patients with ARDS in the intensive care unit room at RSUD dr. Moewardi in January-September 2021 with 485 people. Eighty-three (83) respondents were selected through the purposive sampling technique. The research instrument used the SOFA scoring sheet. Results: The study on the characteristics of respondents revealed that 57.8% were male, the average age of respondents was 57.31 years and 57.8% with comorbid diseases. The abnormal SOFA scores were 96.4%, 91.6% mortality. The Chi-Square test showed a p-value of 0.018.Conclusion: There is a relationship between SOFA scores and mortality in coronavirus disease-19 patients with ARDS. SOFA score could be used as a predictor of mortality in coronavirus disease-19 patients with ARDS. SOFA score scores can describe the patient’s prognosis, because SOFA scores have an assessment of all six organ functions such as respiration (PaO2 / FiO2), blood pressure, creatinine and diuresis, bilirubin, platelets, and GCS, so that it is effective in assessing organ failure.

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  1. Drew, C., & Adisasmita, A. C. (2021). Symptoms and comorbidities affecting mortality of COVID-19 positive patients in East Jakarta, March-September 2020. Tarumanagara Medical Journal, 3(2), 274-283.
  2. Elviani, R., Anwar, C., & Januar Sitorus, R. (2021). Age at COVID-19 incidence. JAMBI MEDICAL JOURNAL “Journal of Medicine and Health,†9(1), 204-209.
  3. Fayed, M., Patel, N., Angappan, S., Nowak, K., Vasconcelos Torres, F., Penning, D. H., & Chhina, A. K. (2022). Sequential Organ Failure Assessment (SOFA) Score and mortality prediction in patients with severe respiratory distress secondary to COVID-19. Cureus, 14(7).
  4. Ferreira, F. L. (2001). Serial evaluation of the SOFA score. October, 286(14), 1754-1758.
  5. Ganesan, R., Mahajan, V., Singla, K., Konar, S., Samra, T., Sundaram, S. K., Suri, V., Garg, M., Kalra, N., & Puri, G. D. (2021). Mortality prediction of COVID-19 patients at intensive care unit admission. Cureus, 13(11).
  6. Guan, W. J., Liang, W. H., He, J. X., & Zhong, N. S. (2020). Cardiovascular comorbidity and its impact on patients with COVID-19. European Respiratory Journal, 55(6), 1069-1076.
  7. Gujski, M., Jankowski, M., Rabczenko, D., Goryński, P., & Juszczyk, G. (2022). The prevalence of acute respiratory distress syndrome (ARDS) and outcomes in hospitalized patients with COVID-19—A Study based on data from the polish national hospital register. Viruses, 14(1).
  8. Kashyap, R., Sherani, K. M., Dutt, T., Gnanapandithan, K., Sagar, M., Vallabhajosyula, S., Vakil, A. P., & Surani, S. (2021). current utility of sequential organ failure assessment score: A literature review and future directions. The Open Respiratory Medicine Journal, 15(1), 1-6.
  9. Khwannimit, B., Bhurayanontachai, R., & Vattanavanit, V. (2018). Comparison of the performance of SOFA, qSOFA and SIRS for predicting mortality and organ failure among sepsis patients admitted to the intensive care unit in a middle-income country. Journal of Critical Care, 44, 156-160.
  10. Liu, S., Yao, N., Qiu, Y., & He, C. (2020). Predictive performance of SOFA and qSOFA for in-hospital mortality in severe novel coronavirus disease. American Journal of Emergency Medicine, 38(January), 2074-2080.
  11. Ma, X. H., An, M. M., Yin, F., Zhang, J., Peng, M. Y., Guan, H., & Gong, P. (2022). Factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19: a retrospective case series. Journal of International Medical Research, 50(5).
  12. Nugrahani, A., & Fauzi, L. (2022). Mortality risk of COVID-19 patients (Retrospective cohort study at COVID-19 referral hospital). Higeia Journal of Public Health Research and Development, 2(2), 227-238.
  13. Putra, M. K., Soemartono, C., Semedi, B. P., & Hardiono. (2021). Use of ventilatory ratio and alveolar dead space fraction as predictors of, mortality in COVID-19 patients with Acute Respiratory Distress Syndrome. Jurnal Anestesi Perioperatif, 9(1), 10-17.
  14. Putri, Putra, & Mariko. (2021). Relationship between age, gender and symptoms with the incidence of COVID-19 in West Sumatra. Research Article, 44(2), 104-111.
  15. Ramananda, N. D., & Khomdram, D. (2020). WHO statement older people are at highest risk from COVID-19 : Should the hypothesis be corroborated or rejected? Medical Hypotheses, 144(January), 19-21.
  16. Rello, J., Belliato, M., & Dimopoulos, M. (2020). Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium. Anaesthesia Critical Care & Pain Medicine, 39(6), 723-730.
  17. Sari, E. K., Hayati, Y. S., & Rokhmawati, N. L. (2021). Comparison of SOFA and qSOFA scores in identifying sepsis patient mortality. Majalah Kesehatan FKUB, 8(3), 149-155.
  18. Rumende, C. M., & Wijaya, I. P. E. (2019). Acute Respiratory Distress Syndrome. 6(2), 109-115.
  19. Setyarini, E. W., & Dwianggimawati, M. S. (2021). Analysis of risk factors for transmission among health workers of the COVID-19 pandemic in Jombang District. Jurnal Inovasi Penelitian, 2(2).
  20. Sirvent, J. M., Baro, A., Morales, M., Sebastian, P., & Saiz, X. (2022). Predictive biomarkers of mortality in critically ill patients with COVID-19. Medicina Intensiva, 46(2), 94-96.
  21. Susilo, A., Rumende, C. M., Pitoyo, C. W., Santoso, W. D., Yulianti, M., Herikurniawan, H., Sinto, R., Singh, G., Nainggolan, L., Nelwan, E. J., Chen, L. K., Widhani, A., Wijaya, E., Wicaksana, B., Maksum, M., Annisa, F., Jasirwan, C. O. M., & Yunihastuti, E. (2020). Coronavirus disease 2019: A review of the current literature. Indonesian Journal of Internal Medicine, 7(1), 45.
  22. Timuda, C. E., Setyawan, U. A., & Djajalaksana, S. (2020). Respiratory parameter has a great impact in determining sepsis condition in COVID-19 patients at Saiful Anwar Hospital Malang: Case report. Medica Hospitalia : Journal of Clinical Medicine, 7(1A), 176-180.
  23. Tomazini, B. M., Maia, I. S., Bueno, F. R., Silva, M. V. A. O., Baldassare, F. P., Costa, E. L. V., Moura, R. A. B., Honorato, M. O., Costa, A. N., Cavalcanti, A. B., Rosa, R. G., Avezum, Ã., Veiga, V. C., Lopes, R. D., Damiani, L. P., Machado, F. R., Berwanger, O., & de Azevedo, L. C. P. (2020). COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. Revista Brasileira de Terapia Intensiva, 32(3), 354-362.
  24. Tushar Gupta, MD1, Michael A. Puskarich, MD2, Elizabeth DeVos, MD, MPH1, Adnan Javed, MD3, Carmen Smotherman, MS4, Sarah A. Sterling, MD2, Henry E. Wang, MD, MS5, Frederick A. Moore, MD6, Alan E. Jones, MD2, Faheem W. Guirgis, M. (2020). Sequential Organ Failure Assessment Component Score prediction of in hospital mortality from sepsis. Physiology & Behavior, 176(3), 139-148.
  25. Wulandari, A., Martuti, S., & Kaswadi, P. (2018). Development of sepsis diagnosis in children. Sari Pediatri, 19(4), 237.
  26. Xie, J., Wu, W., Li, S., Hu, Y., Hu, M., Li, J., Yang, Y., Huang, T., Zheng, K., Wang, Y., Kang, H., Huang, Y., Jiang, L., Zhang, W., Zhong, M., Sang, L., Zheng, X., Pan, C., Zheng, R., … Du, B. (2020). Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study. Intensive Care Medicine, 46(10), 1863-1872.
  27. Yudha, M., Dewi, A., & Irfan, A. (2021). Case report. Perioperatif, Anestesi Journal, 9(13), 127-134.
  28. Yulianto, S., & Indriasari. (2020). Scoring in the ICU (pp. 65-72). Scientific Journal of Health and Environment WIDYA.
  29. Zeng, F., Dai, C., Cai, P., Wang, J., Xu, L., Li, J., Hu, G., Wang, Z., Zheng, F., & Wang, L. (2020). A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: A possible reason underlying different outcome between sex. Journal of Medical Virology, 92(10), 2050-2054.
  30. Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395(10229), 1054-1062.